Vaccine Aluminum Travels Into The Brain
Click for list of papers in this post.
Aluminum adjuvant nanoparticles (AANs) are transported through the body differently than ingested aluminum.
Most vaccines contain aluminum adjuvant, an ingredient necessary for stimulating a strong immune response and immunity. The aluminum is in the form of Al hydroxide and/or Al phosphate nanoparticles.
Aluminum has been used in vaccines since the 1920s. Despite this long history, aluminum adjuvant was not studied much beyond its effect of making vaccines more effective. The safety of injected Al adjuvant was assumed, largely because aluminum is a normal (if unhealthy) component of many foods. Its one of the most common elements of the Earths crust. Its everywhere.
So consideration of Al adjuvant safety was entirely based upon studies of ingested aluminum. Ingested aluminum has a low absorption (about 0.3%), and when this low absorption is taken into account, there is good reason to expect vaccines to create aluminum toxicity. But that is not the subject of the present commentary. Commentary about the total amount of aluminum in vaccines can be found HERE.
The present commentary is concerned with the nanoparticulate form of aluminum in vaccines, and the evidence that aluminum adjuvant nanoparticles (AANs) can be far more toxic than ingested aluminum from food.
Ingested aluminum enters the blood from the gut. In the blood, ingested aluminum is in a water-soluble ionic form, typically Al3+ or an aluminum complex*. This aluminum is separated into individual atoms, like ordinary salt dissolved in water. Ionic aluminum is toxic, but it is blocked from entering the brain by the blood-brain barrier (BBB), and it is rapidly filtered from the blood by the kidneys. Unless large amounts are consumed it does not cause a problem.
Below is a diagram illustrating how ingested aluminum moves through the body. The body’s natural defenses are adequate for preventing harm from normal, natural amounts of ingested aluminum.
Based on on this understanding of ingested aluminum, it was long assumed that AAN follows a similar pathway out of the body. AANs cannot be filtered by the kidneys (they are too large). But it was assumed that the AANs would dissolve in body fluids, and the resulting Al3+ ions (or other Al ions like AlOH4-), would be filtered out by the kidneys, just like ingested aluminum. However, this simple model is wrong.
Below is a diagram illustrating this wrong understanding of how AANs travels through the body.
This model is wrong because what actually happens is that a type of white blood cell called a macrophage (MF) engulfs or “eats” (process is called “phagocytosis”) the AANs before they can dissolve. Eating foreign material is normal behavior for MFs. When MFs detect bacteria or other pathogens, the MFs engulf the pathogens, and digest them with enzymes. They then tell other immune system cells about the pathogen and how to detect it.
The problem with AANs is that they are not digested by the MF enzymes. And the AANs, once inside the MF, dissolve much more slowly. The AANs persist for a long time and cause the MFs to slowly leak aluminum. MFs that consume the AANs become highly contaminated with aluminum, and spread this aluminum around wherever they go. And they go everywhere in the body.
The MFs are able to travel across the blood brain barrier (BBB). The MFs, once loaded with AANs, act like a Trojan Horse and carry the AANs into the brain. This is very harmful, because the brain is very sensitive to aluminum.
Below is a diagram of a more correct model of how AANs travels around the body.
Once inside the brain, the aluminum damages brain cells. The damaged brain cells trigger inflammation which attracts more MFs, some of which are loaded with still more aluminum. The result is a vicious cycle.
The Scientific Evidence
The scientific evidence for this “Trojan Horse” mechanism is quite simple, unequivocal and overwhelming.
First, there is the Flarend study, which shows that even after a month, only about 6% (of Al hydroxide) or 22% (of Al phosphate) are eliminated. Most aluminum adjuvant is retained in the body 1 month after injection (94% of Al hydroxide is retained!). The Flarend study also shows that the aluminum spreads to numerous organs, including the brain. The Flarend study did not determine the form of the retained aluminum, however (dissolved Al ions, or AANs). Flarend full paper: In vivo absorption of aluminium-containing vaccine adjuvants using 26Al (PDF).
The Movsas study (published in 2013) used human infants and obtained similar results. Movsas looked for aluminum in urine and blood before and after routine vaccination with 1200mcg aluminum at the 2-month date. No change in urine or blood levels was observed. Movsas states:
“No significant change in levels of urinary or serum aluminum were seen after vaccination.“
Of course, these results contradict the claims by vaccine advocates that aluminum adjuvant dissolves and is removed by the kidneys. Movsas full paper: Effect of Routine Vaccination on Aluminum and Essential Element Levels in Preterm Infants (PDF).
Several studies show, with certainty, that MFs engulf AANs. In several studies, the AANs have been stained and photographed inside the MFs, and identified using several different methods. This is not surprising because it is well known that MFs will engulf nanoparticles just from being grown in a solution containing nanoparticles. The composition of the nanoparticles does not seem to matter.
This paper describes an experiment proving that AANs are engulfed by human MFs, when grown in culture. See the photographs for yourself. Full paper: Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line (PDF). (Note: a macrophage (MF) is essentially the same as a “monocyte”. THP-1 is a specific macrophage culture used for research).
Another study shows that AANs are present inside MFs at the location of intramuscular vaccine injections. Human tissue samples were analyzed using X-rays, which identified high levels of aluminum inside the MFs. Full paper: Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminum hydroxide in muscle (PDF).
In an impressive study in mice, AANs and other nanoparticles (e.g. latex) were injected intramuscularly into mice. AANs were detected in the brain and spleen, up to one year later. These results contradict the long-assumed “100% of adjuvant dissolves into the blood” belief preferred by vaccine advocates. Full paper: Slow CCL2-dependent translocation of biopersistent particles from muscle to brain (PDF).
(Note: CCL2 is an immune system signal that attracts MFs; it increases the transport of the nanoparticles. The effect of CCL2 is further evidence that it’s the MFs doing the transporting. CCL2 is described HERE). CCL2 is also known as “MCP-1″ (macrophage chemo-attractant protein, a very descriptive name since MCP-1 attracts macrophages). Below is a page from this paper showing that AANs were detected in the brain and spleen.
Images of AANs in brain and spleen. These particles traveled into the brain from the distant site of intramuscular injection. AANs are not rapidly dissolved and excreted, as vaccine advocates claim. D21, D180, D365 indicate time (in days) between AAN injection, and detection in the brain.
Studies show that CCL2/MCP-1 production is stimulated by immune activation and vaccines. So in the case of vaccines, AANs are injected at the same time the immune system is producing CCL2/MCP-1. Hence, a vaccine provides all conditions necessary for AAN transport into the brain. See our article on immune activation HERE.
Finally, the Trojan Horse mechanism of MF-transport of nanoparticles has been studied for applications in getting drugs into the brain (through the BBB). Studies have been done proving that nanoparticles, serotonin, or HIV drugs can be transported through the BBB using macrophages. In one specific study, the Trojan Horse mechanism was used to transport nanoparticles into a brain tumor (as a proof-of-principle experiment with the ultimate goal of transporting cancer drugs into the brain). In this study, human MFs engulfed nanoparticles (made of silica-gold). The particle-loaded MFs were then injected into mice (into the tail) and the particle-loaded MFs were detected in the brain tumor 24 hours later. Full paper: Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan Horse (PDF).
(Choi et al., Delivery of Nanoparticles to Brain Using Cellular Trojan Horse):
“More than two decades ago, Fidler and colleagues provided evidence that macrophages of blood monocyte origin can infiltrate experimental brain metastases while the blood–brain barrier is intact (Schackert et al. 1988). Even earlier, Morantz and colleagues had quantified the content of macrophages in clinical specimens (Morantz et al. 1979).”
“The use of monocyte/macrophages as delivery vehicles to the CNS has been investigated in situations other than malignancy. Afergan et al. demonstrated the delivery of serotonin to the brain by monocytes, which had phagocytosed nano-liposomes containing this otherwise brain impermeant drug (Afergan et al. 2008). Dou and colleagues utilized bone marrow derived macrophages as carriers of and depots for antiretroviral drugs to treat and attenuate the symptoms of HIV-associated neurocognitive disorder (Dou et al. 2009). Therefore, we hypothesized that nanoparticle-laden monocytes/macrophages would home in to intracranial meta- static deposits by crossing the blood–brain barrier following injection into the systemic circulation.”
Every step has been proven: MFs engulfing of Al nanoparticles, MFs crossing the BBB and MFs carrying nanoparticles into the brain has been experimentally demonstrated and proven multiple times. And the entire process has been demonstrated with AANs in mice. AANs from an intramuscular injection were “photographed” in the brain. These facts contradict the simplistic view (preferred by vaccine advocates) of aluminum toxicity based only on the concentration of dissolved aluminum ions in the blood. The story is far more complicated and worrisome than that. The toxicity of aluminum adjuvant depends critically on the transport of Al nanoparticles by MFs, through the blood-brain barrier.
Elevated MCP-1/CCL2 in Autistic Brain
Further, MCP-1/CCL2 is elevated in the autistic brain and spinal fluid. This was one of the most significant findings of the Vargas study: Neuroglial Activation and Neuroinflammation in the Brain of Patients with Autism (PDF). Vargas stated:
“MCP-1 and TGF-B1 are the most prominent cytokines in the brain of autistic patients.”
“MCP-1, a chemokine involved in innate immune reactions and important mediator for monocyte and T-cell activation and trafficking into areas of tissue injury, appeared to be one of the most relevant proteins found in cytokine protein array studies because it was significantly elevated in both brain tissues and cerebro-spinal fluid.“
This of course means that in autism, injected AANs will be transported by MFs into the brain from a distant intramuscular injection site. MCP-1 attracts macrophages, and the macrophages are loaded with aluminum.
If you would like to read more about this hugely important issue, VP recommends the following review paper by Dr Romain Gherardi (the researcher who made the photos above, of AANs in the brain and spleen of vaccine-injected mice). Paper is here: Biopersistence and brain translocation of aluminum adjuvants of vaccines (PDF).
AANs: Aluminum adjuvant nanoparticles. Used in most vaccines.
BBB: Blood brain barrier. Protects brain from aluminum in normal conditions.
MF: Macrophage (same thing as monocyte). A type of white blood cell. Can travel through the BBB.
CNS: Central nervous system (brain + spinal cord).
CCL2/MCP-1: Macrophage chemoattractant protein. Immune system signaling substance that attracts MFs. Causes MFs to transport aluminum into the brain and around the body.
* Under physiologic conditions, some dissolved aluminum will not be in the Al3+ form, but rather AlOH4-. For the sake of this discussion, this is irrelevant, so we will use Al3+, even though this is not really correct. But AlOH4- arguably contains Al3+ in the center.
Monocytes and macrophages are basically the same thing. From nature.com: “Macrophages (and their precursors, monocytes) are the ‘big eaters’ of the immune system. These cells reside in every tissue of the body, albeit in different guises — such as microglia (brain), Kupffer cells (liver) and osteoclasts (bone) — where they engulf apoptotic cells and pathogens and produce immune effector molecules. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they differentiate into tissue macrophages. Macrophages are remarkably plastic and can change their functional phenotype depending on the environmental cues they receive. Through their ability to clear pathogens and instruct other immune cells, these cells have a central role in protecting the host but also contribute to the pathogenesis of inflammatory and degenerative diseases.”
Source: Vaccine Papers
Disclaimer: This article is not intended to provide medical advice, diagnosis, or treatment. Views expressed here do not necessarily reflect those of Gardasil Awareness NZ or their volunteers.